1. CRISPRi-mediated knock-down of PRDM1/BLIMP1 programs central memory differentiation in ex vivo-expanded human T cells

Mohammad Azadbakht , Ali Sayadmanesh, Naghme Nazer, Amirhossein Ahmadi, Sara Hemmati, Hoda Mohammadzade, Marzieh Ebrahimi, Hossein Baharvand, Babak Khalaj, Mahmoud Reza Aghamaali* , Mohsen Basiri*

BioImpacts. 2022;12(4): 337-347. doi: 10.34172/bi.2021.23522

PMCID: PMC9376159 PMID: 35975204 Scopus ID: 85137404752

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PRDM1/BLIMP1 expression is increased during differentiation from naïve to effector T cell.CRISPRi-mediated suppression of this transcription factor in ex vivo-expanded primary human T cellsresulted in increased central memory phenotype in human T cells.

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